Ana Cristina Grodzki, PhD – Department of Molecular Biosciences

Developmental exposure to organophosphorus pesticide to evaluate airway hyperreactivity Epidemiological studies have linked organophosphorus pesticide (OP) exposure to increased risk of asthma in children and adults, yet preclinical evidence supporting this causal link is limited. Dr. Grodzki’s previous work has shown that the OP chlorpyrifos causes airway hyperreactivity (AHR) at low doses that do not inhibit acetylcholinesterase. However, current understanding of the mechanisms involved in OP-induced AHR is incomplete and the question of whether developmental OP exposure could lead to asthmatic symptoms has not been addressed in preclinical models. Dr. Grodzki is investigating the effects of developmental chlorpyrifos exposures on AHR using physiological measurements of lung function and markers of neurogenic inflammation in animal models.